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Cardiac Biomechanics Lab

Co-Lab Director

Mark Ratcliffe, M.D.

Professor & Chief of Surgery,
SFVA Medical Center

Co-Director, Cardiac Biomechanics Lab

Our Research »

Co-Lab Director

Julius M. Guccione, PhD

Associate Professor of Surgery, UCSF

Core Member, UCB/UCSF Bioengineering Graduate Group

Co-Director, Cardiac Biomechanics Lab

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Featured Video

A movie created from a finite element model of the left ventricle + mitral valve. The model is based on  MRI images of a sheep with moderate ischemic mitral regurgitation [Wenk et al, Ann Thorac Surg, 89: 1546, 2010].

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Welcome to the Cardiac Biomechanics Lab Site

 Our lab uses state of the art mechanical engineering analysis to determine the cause and to design treatments for the ventricular remodeling and heart failure that occurs after myocardial infarction.

Areas of Focus: 

Research Tools:

 

Recent Publications

Sun K, Zhang Z, Suzuki T, Wenk JF, Stander N, Einstein DR, Saloner DA, Wallace AW, Guccione JM, Ratcliffe MB
Dor procedure for dyskinetic anteroapical myocardial infarction fails to improve contractility in the border zone.
The Journal of thoracic and cardiovascular surgery, Jul-01-2010; 1401: 233-9, 239.e1-4.  Epub 2010 Mar 17.
Wenk JF, Zhang Z, Cheng G, Malhotra D, Acevedo-Bolton G, Burger M, Suzuki T, Saloner DA, Wallace AW, Guccione JM, Ratcliffe MB
First finite element model of the left ventricle with mitral valve: insights into ischemic mitral regurgitation.
The Annals of thoracic surgery, May-01-2010; 895: 1546-53.
Carson JP, Kuprat AP, Jiao X, Dyedov V, Del Pin F, Guccione JM, Ratcliffe MB, Einstein DR
Adaptive generation of multimaterial grids from imaging data for biomedical Lagrangian fluid-structure simulations.
Biomechanics and modeling in mechanobiology, Apr-01-2010; 92: 187-201.  Epub 2009 Sep 2.
Jhun CS, Wenk JF, Zhang Z, Wall ST, Sun K, Sabbah HN, Ratcliffe MB, Guccione JM
Effect of adjustable passive constraint on the failing left ventricle: a finite-element model study.
The Annals of thoracic surgery, Jan-01-2010; 891: 132-7.
Ge L, Sotiropoulos F
Direction and magnitude of blood flow shear stresses on the leaflets of aortic valves: is there a link with valve calcification?.
Journal of biomechanical engineering, Jan-01-2010; 1321: 014505.
Azadani AN, Jaussaud N, Matthews PB, Ge L, Guy TS, Chuter TA, Tseng EE
Energy loss due to paravalvular leak with transcatheter aortic valve implantation.
The Annals of thoracic surgery, Dec-01-2009; 886: 1857-63.
Azadani AN, Jaussaud N, Matthews PB, Ge L, Guy TS, Chuter TA, Tseng EE
Valve-in-valve implantation using a novel supravalvular transcatheter aortic valve: proof of concept.
The Annals of thoracic surgery, Dec-01-2009; 886: 1864-9.
Dwyer HA, Matthews PB, Azadani A, Ge L, Guy TS, Tseng EE
Migration forces of transcatheter aortic valves in patients with noncalcific aortic insufficiency.
The Journal of thoracic and cardiovascular surgery, Nov-01-2009; 1385: 1227-33.  Epub 2009 Sep 13.
Sun K, Stander N, Jhun CS, Zhang Z, Suzuki T, Wang GY, Saeed M, Wallace AW, Tseng EE, Baker AJ, Saloner D, Einstein DR, Ratcliffe MB, Guccione JM
A Computationally Efficient Formal Optimization of Regional Myocardial Contractility in a Sheep with Left Ventricular Aneurysm.
Journal of biomechanical engineering, Nov-01-2009; 13111: 111001.
Dwyer HA, Matthews PB, Azadani A, Jaussaud N, Ge L, Guy TS, Tseng EE
Computational fluid dynamics simulation of transcatheter aortic valve degeneration.
Interactive cardiovascular and thoracic surgery, Aug-01-2009; 92: 301-8.  Epub 2009 May 4.
Gundiah N, Matthews PB, Karimi R, Azadani A, Guccione J, Guy TS, Saloner D, Tseng EE
Significant material property differences between the porcine ascending aorta and aortic sinuses.
The Journal of heart valve disease, Nov-01-2008; 176: 606-13.
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